Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain

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Science  24 Jun 1983:
Vol. 220, Issue 4604, pp. 1401-1403
DOI: 10.1126/science.6602380


Borna virus replicated persistently in the brains of rats, causing frenzied and apathetic behavioral states in sequence but no mortality. The transient frenzied behavior was caused by an immune-mediated, cytolytic, encephalitic response that was unexpectedly self-limiting. Cessation of active pathological processes coincided with the onset of the passive phase of the disease. This study thus demonstrates suppression of virus-specific inflammation despite continuous viral replication and describes a new mechanism by which chronic encephalitis may become established.

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