Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A

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Science  01 Jul 1983:
Vol. 221, Issue 4605, pp. 63-65
DOI: 10.1126/science.6407112


Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.