Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes

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Science  15 Jul 1983:
Vol. 221, Issue 4607, pp. 283-286
DOI: 10.1126/science.6407114


The polymorphism of immune response genes plays a critical role in determining the immune capabilities of a particular individual. The molecular nature of this polymorphism was studied by examining the structure of the coding portions of three alleles of the I-A beta chain gene, an immune response gene whose protein product constitutes a subunit of the I-A molecule. Comparison of the I-A beta chains encoded by these alleles revealed an amino acid sequence divergence of 5 to 8 percent. The differences were found to be a series of short alterations clustered in the amino terminal half of the polypeptide.