Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation

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Science  29 Jul 1983:
Vol. 221, Issue 4609, pp. 462-464
DOI: 10.1126/science.6346487


Insulin directly inhibits protein phosphorylation in isolated rat liver nuclear envelopes. In the present studies, an antiserum to insulin receptor as well as the plant lectins concanavalin A and phytohemagglutinin mimicked insulin action in isolated nuclear envelopes. These studies suggest that insulin and agents that mimic it may directly regulate nuclear functions.