Endogenous inhibitors of monoamine oxidase present in human cerebrospinal fluid

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Science  29 Jul 1983:
Vol. 221, Issue 4609, pp. 476-478
DOI: 10.1126/science.6867724


Inhibitory activity against the enzyme monoamine oxidase is present in low molecular weight fractions (less than 100,000) of human cerebrospinal fluid. These endogenous substances of different molecular weights (3000 to more than 35,000) act like monoamine oxidase inhibitor drugs to inhibit both type A and type B monoamine oxidase.