Potent interaction between glucocorticoids and growth hormone-releasing factor in vivo

See allHide authors and affiliations

Science  05 Aug 1983:
Vol. 221, Issue 4610, pp. 556-558
DOI: 10.1126/science.6408735


Administration of dexamethasone significantly enhanced the pituitary growth hormone response to growth hormone-releasing factor in intact as well as adrenalectomized rats. Thus the inhibitory effects of glucocorticosteroids on somatic growth which involve an interaction of these steroids and growth hormone at a peripheral level may also involve a modification of pathways within the central nervous system that regulate normal growth hormone secretion.