Pancreatic islet allograft prolongation by donor-specific blood transfusions treated with ultraviolet irradiation

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Science  19 Aug 1983:
Vol. 221, Issue 4612, pp. 754-756
DOI: 10.1126/science.6410509


Survival of allografts of islets of Langerhans in nonimmunosuppressed adult rats was prolonged by transfusions of donor blood irradiated with ultraviolet light before transplantation across a major histocompatibility barrier. This treatment is donor blood-specific and has produced greater than 160-day survival of transplanted islets without the administration of immunosuppressive agents.