Cocaine-induced rotation: sex-dependent differences between left- and right-sided rats

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Science  19 Aug 1983:
Vol. 221, Issue 4612, pp. 775-777
DOI: 10.1126/science.6879177


Cocaine elicited dose-related rotation (circling) in naive rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results suggest that sex-dependent differences in brain asymmetry may be an important determinant of cocaine sensitivity.