Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15

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Science  26 Aug 1983:
Vol. 221, Issue 4613, pp. 867-869
DOI: 10.1126/science.6308764


The mouse homolog (c-sis) of the transforming gene of the simian sarcoma virus was mapped to chromosome 15 by the Southern blot analysis of DNA's from hamster-mouse somatic cell hybrids. Alterations in c-sis expression may thus play a role in the various murine neoplastic diseases characterized by rearrangements or duplications of chromosome 15.