Otosclerotic lesions in the inbred LP/J mouse

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Science  26 Aug 1983:
Vol. 221, Issue 4613, pp. 881-882
DOI: 10.1126/science.6879187


Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.