Haloperidol-induced plasticity of axon terminals in rat substantia nigra

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Science  02 Sep 1983:
Vol. 221, Issue 4614, pp. 969-971
DOI: 10.1126/science.6879197


An electron micrographic morphometric analysis of nerve endings in substantia nigra of rats repeatedly treated with haloperidol was performed. Although most parameters showed no difference, drug-treated animals exhibited a significant shift in the distribution of relative numbers of axon terminals, suggesting neuroleptic-induced axon-collateral sprouting.