Opiate antagonists improve spatial memory

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Science  02 Sep 1983:
Vol. 221, Issue 4614, pp. 975-976
DOI: 10.1126/science.6879198


Rats trained on an eight-arm radial maze were challenged by placing the maze in new spatial environments. Administration of opiate antagonists, either naloxone or diprenorphine, after exposure to the new environments significantly improved subsequent performance. The effect of naloxone on spatial memory was attenuated when drug administration occurred 2 hours after maze exposure.