Burst discharge in mammalian neuroendocrine cells involves an intrinsic regenerative mechanism

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Science  09 Sep 1983:
Vol. 221, Issue 4615, pp. 1050-1052
DOI: 10.1126/science.6879204


Intracellular recordings from mammalian neuroendocrine cells showed that steady, injected currents can modify and block periodic spike bursts previously associated with increased neurohormone release. Spike afterpotentials could sum to form plateau potentials, which generated bursts and did not depend on axonal conduction or chemical synapses. Therefore, bursting involves a spike-dependent, positive-feedback mechanism endogenous to single neuroendocrine cells.