A cholinergic-sensitive channel in the cat visual system tuned to low spatial frequencies

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Science  09 Sep 1983:
Vol. 221, Issue 4615, pp. 1076-1078
DOI: 10.1126/science.6879206


Visually evoked responses to counterphased gratings were recorded from the cat visual cortex before and after physostigmine administration. Physostigmine markedly reduced the responses to low spatial frequencies, but minimally affected the response to high frequencies. This effect is considered cholinergic since it could be reversed by atropine. These results support at least a two-channel model of spatial frequency responsivity.