Selective recording and stimulation of individual identified neurons in freely behaving Aplysia

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Science  16 Sep 1983:
Vol. 221, Issue 4616, pp. 1203-1206
DOI: 10.1126/science.6612336


A neuroethological technique is described for selective recording and stimulation of an individual neuron in freely behaving Aplysia by means of a fine wire glued into the connective tissue sheath above the identified cell body. A whole-nerve cuff electrode simultaneously monitored functionally related multiunit axon activity. For biophysical analysis the soma was impaled with a microelectrode when the ganglion was subsequently exposed. The technique is illustrated for several identified neurons involved in different behaviors.