Modulation of the metastatic capability in B16 melanoma by cell shape

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Science  23 Sep 1983:
Vol. 221, Issue 4617, pp. 1307-1310
DOI: 10.1126/science.6612347


The lung colonization of B16-F1 cells grown in flat and spherical configurations was studied. Cells cultivated in vitro as spheroids on a nonadhesive substrate expressed in a reversible fashion a marked increase in their propensity to establish metastases. The altered metastatic capability was accompanied by a reversible reduction in the accessibility of cell surface proteins to external iodination and by a dramatic decrease in the synthesis of vimentin.