Pregnancy interception with a combination of prostaglandins: studies in monkeys

See allHide authors and affiliations

Science  30 Sep 1983:
Vol. 221, Issue 4618, pp. 1407-1409
DOI: 10.1126/science.6612350

This article has a correction. Please see:


Treatment with combinations of synthetic prostaglandins, one with an ovarian site of action and one with a uterine site of action, terminated pregnancy in all rhesus monkeys given the injection on day 28 of fertile menstrual cycles. Single prostaglandins, even at higher doses, interrupted pregnancy in only one-third of the monkeys. The most effective treatment, 5-oxa-17-phenyl-18,19,20-trinor prostaglandin F1 alpha methyl ester plus 9-deoxo-16,16-dimethyl-9-methylene prostaglandin E2, promptly intercepted early pregnancy after a single administration and without side effects.