Reports

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye

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Science  14 Oct 1983:
Vol. 222, Issue 4620, pp. 169-172
DOI: 10.1126/science.6623064

Abstract

Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.