Reports

Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells

Science  21 Oct 1983:
Vol. 222, Issue 4621, pp. 330-332
DOI: 10.1126/science.6623079

Abstract

Fluoride is one of the most potent but least well understood stimulators of bone formation in vivo. Bone formation was shown to arise from direct effects on bone cells. Treatment with sodium fluoride increased proliferation and alkaline phosphatase activity of bone cells in vitro and increased bone formation in embryonic calvaria at concentrations that stimulate bone formation in vivo.

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