Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family

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Science  28 Oct 1983:
Vol. 222, Issue 4622, pp. 417-419
DOI: 10.1126/science.6604942


The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.