Genes of the major histocompatibility complex in mouse and man

See allHide authors and affiliations

Science  18 Nov 1983:
Vol. 222, Issue 4625, pp. 727-733
DOI: 10.1126/science.6356354


The genes of the major histocompatibility complex code for cell-surface molecules that play an important role in the generation of the immune response. These genes and molecules have been studied intensively over the last five decades by geneticists, biochemists, and immunologists, but only recently has the isolation of the genes by molecular biologists facilitated their precise characterization. Many surprising findings have been made concerning their structure, multiplicity, organization, function, and evolution.