Insertion sequence duplication in transpositional recombination

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Science  18 Nov 1983:
Vol. 222, Issue 4625, pp. 755-765
DOI: 10.1126/science.6314502


Insertion sequences (IS) are discrete segments of DNA that can transpose from one genomic site to another and promote genetic rearrangements. A question that is central to understanding the mechanism of transpositional recombination is whether genetic rearrangements are accompanied by duplication of the IS that promotes them. Analysis of adjacent deletions mediated by IS903 provides the strongest evidence to date than any IS-mediated transpositional recombination can occur by an efficient replicative mechanism.