Effect of prior immunization on induction of cervial cancer in mice by herpes simplex virus type 2

Science  09 Dec 1983:
Vol. 222, Issue 4628, pp. 1128-1129
DOI: 10.1126/science.6316503


Previous studies at this laboratory showed that repeated application of inactivated herpes simplex virus type 2 to the mouse cevix produced premalignant and malignant lesions. In the present study mice were inoculated with inactivated herpes simplex virus type 2 or control solution and Freund's adjuvant by intraperitoneal and subcuaneous routes before exposure of the cervix to inactivated virus. It appears that immunization with inactivated virus conferred a protection against the induction of cervical carcinoma.