Articles

Amphiphilic secondary structure: design of peptide hormones

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Science  20 Jan 1984:
Vol. 223, Issue 4633, pp. 249-255
DOI: 10.1126/science.6322295

Abstract

Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.