Activation of pontine cholinergic sites implicated in unconsciousness following cerebral concussion in the cat

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Science  20 Jan 1984:
Vol. 223, Issue 4633, pp. 301-303
DOI: 10.1126/science.6701514


Low levels of cerebral concussion in the cat produce reversible behavioral suppression presumably associated with unconsciousness. This injury is also associated with increased rates of glucose utilization in regions within the dorsomedial pontine tegmentum. Microinjection of carbachol into these regions produced behavioral suppression resembling that following concussion. These data, together with previously published observations on cholinergic responses to brain injury, suggest that concussive unconsciousness may be attributable in part to activation of cholinergic pontine sites.