Expression of glial fibrillary acidic protein in immature oligodendroglia

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Science  27 Jan 1984:
Vol. 223, Issue 4634, pp. 407-409
DOI: 10.1126/science.6197755


In the human fetal spinal cord at 15 to 16 weeks, glial fibrillary acidic protein (GFAP) was demonstrated within the cytoplasm and processes of cells having the cytological, ultrastructural, and immunocytochemical features of oligodendrocytes--including processes that extend into and contribute to the formation of myelin sheaths. By 17 to 18 weeks, however, GFAP immunoreactivity was no longer evident within such cells. Thus GFAP is expressed by myelin-forming oligodendroglia early in their development.