Prenatal exposure to carbon monoxide: learning and memory deficits

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Science  27 Jan 1984:
Vol. 223, Issue 4634, pp. 409-411
DOI: 10.1126/science.6691152

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Exposing pregnant rats to carbon monoxide (150 parts per million) produced only minor reductions in the birth weights of the pups and gave no evidence of overt teratogenesis. However, behavioral evaluation of learning and memory processes in a two-way avoidance task suggested a functional deficit in the central nervous system of the exposed offspring. Multiple dependent measures and specific control groups confirmed that this deficit was independent of nonassociative or motivational alterations.