Antigenic similarity between cells transformed by ultraviolet radiation in vitro and in vivo

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Science  10 Feb 1984:
Vol. 223, Issue 4636, pp. 593-594
DOI: 10.1126/science.6695169


Cells of the 10T 1/2 mouse fibroblast line transformed in vitro by ultraviolet radiation are antigenically similar to those from skin cancers produced in mice by repeated exposure to ultraviolet radiation. Both types of tumor cells grew preferentially in ultraviolet-irradiated syngeneic mice relative to untreated animals, and both were recognized by ultraviolet radiation-induced tumor-specific suppressor lymphocytes. These properties were not shared by 10T 1/2 cells transformed in vitro by x-rays or 3-methylcholanthrene.