Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft

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Science  10 Feb 1984:
Vol. 223, Issue 4636, pp. 607-609
DOI: 10.1126/science.6420888


Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.