Free-Radical Carbon-Carbon Bond Formation in Organic Synthesis

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Science  02 Mar 1984:
Vol. 223, Issue 4639, pp. 883-887
DOI: 10.1126/science.223.4639.883


Organic chemists have begun to use intra- and intermolecular free-radical addition reactions to develop useful synthetic transformations. Carboncentered radicals can form bonds with electron-rich or electron-deficient alkenes, allenes, and acetylenes. Radical addition reactions can also be used to construct hindered carbon-carbon bonds. These characteristics, as well as the large number of functional groups that tolerate free-radical conditions contribute to the importance of such reactions in organic synthesis.