Reports

Estradiol is concentrated in tyrosine hydroxylase-containing neurons of the hypothalamus

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Science  02 Mar 1984:
Vol. 223, Issue 4639, pp. 938-940
DOI: 10.1126/science.6141639

Abstract

Localization of [3H]estradiol in tyrosine hydroxylase-containing neurons of rat brain was shown by a combined technique of autoradiography and immunohistochemistry. [3H]Estradiol was concentrated in the nuclei of tyrosine hydroxylase-containing neurons in the nucleus arcuatus, nucleus periventricularis hypothalami, and the zona incerta. These results suggest that estradiol acts directly on dopamine-producing neurons of the tuberoinfundibular system and incertohypothalamic system.