Insulin receptor phosphorylation may not be a prerequisite for acute insulin action

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Science  23 Mar 1984:
Vol. 223, Issue 4642, pp. 1301-1304
DOI: 10.1126/science.6367041


An antiserum to the insulin receptor mimicked insulin's acute actions on glucose transport, phosphorylation of integral membrane proteins, and internalization of the insulin receptor in isolated rat adipose cells. These insulinomimetic actions of the antiserum occurred without the equivalent increase in phosphorylation of the beta subunit of the insulin receptor observed with insulin. Thus, a role of receptor phosphorylation in acute insulin action is now questioned.