Reports

Increased phosphorylation of myosin light chain kinase after an increase in cyclic AMP in intact smooth muscle

Science  30 Mar 1984:
Vol. 223, Issue 4643, pp. 1415-1417
DOI: 10.1126/science.6322302

Abstract

The role of cyclic adenosine monophosphate-mediated phosphorylation of myosin light chain kinase in relaxing smooth muscle was examined. The kinase was immunoprecipitated from tissue extracts and the phosphate content was determined. The addition of forskolin to resting or methacholine-contracted muscles resulted in an increase in myosin light chain kinase phosphorylation of myosin light chain kinase is one of the reactions in the process by which cyclic adenosine monophosphate causes relaxation of smooth muscle.

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