Sequence of the human somatostatin I gene

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Science  13 Apr 1984:
Vol. 224, Issue 4645, pp. 168-171
DOI: 10.1126/science.6142531


Two human genomic DNA fragments containing alleles for the gene coding for somatostatin I were isolated and sequenced. This gene contains a single intron that interrupts the coding sequence in the propeptide portion of the somatostatin moiety. The site of initiation of transcription of the gene was located by transcription experiments in HeLa cell extracts, and the putative regions for controlling the initiation of transcription were identified.