Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture

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Science  20 Apr 1984:
Vol. 224, Issue 4646, pp. 303-306
DOI: 10.1126/science.6143400

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Ganglion cells were dissociated from postnatal rat retinas, identified by specific fluorescent labels, and maintained in culture on a variety of substrates. Regeneration of processes by retinal ganglion cells was enhanced when the cells were plated on glass coated with a monoclonal antibody against the Thy-1 determinant. Plain glass and glass coated with polylysine, collagen, fibronectin, or other monoclonal antibodies supported the growth of neural processes, but were less effective than antibody to Thy-1.