Reports

Reactive metabolites from the bioactivation of toxic methylfurans

Science  25 May 1984:
Vol. 224, Issue 4651, pp. 884-886
DOI: 10.1126/science.6719117

Abstract

An important mechanism of toxicity of furans involves the cytochrome P-450 monooxygenase-catalyzed bioactivation of the compound in situ directly within the target tissues to highly reactive electrophilic products. The unsaturated aldehydes acetylacrolein and methylbutenedial have been identified as the principal reactive intermediates of 2- and 3-methylfuran, respectively, that are produced and bound covalently to tissue macromolecules in hepatic and pulmonary microsomal systems in vitro.

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