Androgen modulation of adrenal angiotensin receptors

Science  01 Jun 1984:
Vol. 224, Issue 4652, pp. 1009-1011
DOI: 10.1126/science.6326265


Several polar androgens increased the binding of angiotensin and its stimulation of aldosteronogenesis in bovine adrenal glomerulosa cells. The effect was seen only if the steroids were applied to the cells and then washed away. This phenomenon and the technique for demonstrating it may have implications for studies of receptor modulation and for clinical states in which responsiveness to angiotensin is increased.