Dietary restriction retards age-related loss of gamma crystallins in the mouse lens

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Science  15 Jun 1984:
Vol. 224, Issue 4654, pp. 1247-1249
DOI: 10.1126/science.6729452


The soluble crystallins in lenses from diet-restricted and control mice of diverse ages (2, 11, or 30 months) were studied by high-performance liquid chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Results obtained with both methods suggest that dietary restriction decelerates age-related loss of soluble gamma crystallins.