GM1 ganglioside treatment facilitates behavioral recovery from bilateral brain damage

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Science  20 Jul 1984:
Vol. 225, Issue 4659, pp. 340-342
DOI: 10.1126/science.6740316


Adult rats with bilateral lesions of the caudate nucleus were treated with GM1 ganglioside. Although animals injected with a control solution were severely impaired in their ability to learn a complex spatial task, those treated with ganglioside were able to learn spatial reversals.