Single channel studies on inactivation of calcium currents

Science  27 Jul 1984:
Vol. 225, Issue 4660, pp. 432-434
DOI: 10.1126/science.6330896


Inactivation of calcium channels has been attributed to a direct reaction of calcium ions entering the cell with the calcium channel. For a single channel this hypothesis predicts a correlation between the amount of calcium entering during an opening or a burst of openings and the subsequent closed times. No such correlation was found, and the possibility that, upon entry, calcium ions produce inactivation is excluded.