Reports

Independent developmental programs for two estrogen-regulated genes

Science  10 Aug 1984:
Vol. 225, Issue 4662, pp. 639-641
DOI: 10.1126/science.6740331

Abstract

Measurement of hepatic apolipoprotein II and vitellogenin II messenger RNA during chicken embryogenesis showed that these genes acquire estrogen responsiveness at different stages of development. Sensitive solution hybridization assays with excess complementary DNA showed that apolipoprotein II transcripts were induced to 500 molecules per cell at day 9, whereas induction of vitellogenin II messenger RNA was not found until day 11. Thus, two estrogen regulated genes of common function and coordinately regulated in the adult may be on independent developmental programs.

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