Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene

Science  17 Aug 1984:
Vol. 225, Issue 4663, pp. 718-721
DOI: 10.1126/science.6463648


Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65Kc-myc protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.