Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes

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Science  17 Aug 1984:
Vol. 225, Issue 4663, pp. 743-745
DOI: 10.1126/science.6087456


Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.