Identified interneurons produce both primary afferent depolarization and presynaptic inhibition

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Science  24 Aug 1984:
Vol. 225, Issue 4664, pp. 854-856
DOI: 10.1126/science.6474158


Crayfish interneurons were identified that appear to be directly responsible for presynaptic inhibition of primary afferent synapses during crayfish escape behavior. The interneurons are fired by a polysynaptic pathway triggered by the giant escape command axons. When directly stimulated, these interneurons produce short-latency, chloride-dependent primary afferent depolarizations and presynaptically inhibit primary afferent input to mechanosensory interneurons.