Distinctive termini characterize two families of human endogenous retroviral sequences

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Science  31 Aug 1984:
Vol. 225, Issue 4665, pp. 943-947
DOI: 10.1126/science.6089336


Human DNA contains many copies of endogenous retroviral sequences. Characterization of molecular clones of these structures reveals the existence of two related families. One family consists of full-length (8.8 kilobases) proviral structures, with typical long terminal repeates (LTR's). The other family consists of structures, which contain only 4.1 kilobases of gag-pol sequences, bounded by a tandem array of imperfect repeats 72 to 76 base pairs in length. Typical LTR sequences that exist as solitary elements in the genome were cloned and characterized.