Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts

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Science  31 Aug 1984:
Vol. 225, Issue 4665, pp. 949-951
DOI: 10.1126/science.6382608


Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.