Prostaglandin E2: a neuromodulator in the central control of gastrointestinal motility and feeding behavior by calcitonin

See allHide authors and affiliations

Science  07 Sep 1984:
Vol. 225, Issue 4666, pp. 1050-1052
DOI: 10.1126/science.6591429


Two micrograms of prostaglandin E2 injected into the lateral ventricle of the brain in rats had the same anorectic and gastrointestinal motor effect as central administration of 0.02 unit of calcitonin. The effects of calcitonin were blocked by a previous intracerebroventricular administration of 0.25 milligram of indomethacin. These results suggest that both anorectic and gastrointestinal motor effects of calcitonin are centrally mediated by the release of prostaglandins.