Insulin-mediated regulation of neuronal maturation

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Science  14 Sep 1984:
Vol. 225, Issue 4667, pp. 1170-1172
DOI: 10.1126/science.6089343


Exposure to insulin increased stimulus-evoked transmission at synapses formed in culture by cholinergic retinal neurons derived from fetal rats. This effect occurred at physiological concentrations and was long lasting. The findings support the hypothesis that insulin may serve as a developmental signal to regulate the emergence of effective neurotransmission across nascent synapses.