Chemical anatomy of the brain

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Science  21 Sep 1984:
Vol. 225, Issue 4668, pp. 1326-1334
DOI: 10.1126/science.6147896


The development of sensitive histochemical-neuroanatomical techniques has made it possible to analyze the content of specific compounds in single nerve cells and their processes. In consequence, it has been possible to construct detailed maps of the distribution of various types of neurons on the basis of their transmitter substance. There are now many examples of neurons containing both a classical transmitter and a peptide. In some instances the peptides seem to support the action of the classical transmitters. This interaction may have applications in the prevention and treatment of nervous disease states.