Interruption of the mammillothalamic tract prevents seizures in guinea pigs

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Science  05 Oct 1984:
Vol. 226, Issue 4670, pp. 72-74
DOI: 10.1126/science.6433485


Interruption of the connection between the mammillary bodies and the anterior nucleus of the thalamus in guinea pigs, by discrete bilateral electrolytic lesions of the mammillothalamic tract, resulted in essentially complete protection from the behavioral and electroencephalographic convulsant action and lethal effect of pentylenetetrazol. This result demonstrates that the mammillary bodies and their rostral efferent connections are important for the propagation and perhaps initiation of generalized seizures.